Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Red & White Blood Cells Basicmedical Key In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are The Electron Transport Chain and Pentose Phosphate Pathway biochemistry Storage lesion: History and perspectives